In 2018, there were 115,045 new syphilis cases reported in the United States. In 2019, this increased to 129,813 reported cases of all stages of syphilis, including 38,992 cases of primary and secondary syphilis, which is the most infectious stages of the disease.
In 2019, there were 1,870 reported cases of congenital syphilis (when the fetus acquires syphilis before birth).
Syphilis infections were estimated to have a direct medical cost to the US healthcare system of $174 million in 2018. However, this direct medical cost is far lower than the total cost associated with syphilis, as it does not include costs associated with lost productivity, other non-medical costs, and STI prevention.